Is the particle deposition in a cell exposure facility comparable to the lungs? A computer model approach

Abstract

Cell exposure experiments at the air-liquid interface (ALI) are used increasingly as indicators for health effects and for the impact of aerosols on the lung. Thereby the aerosol particles are kept airborne and can deposit on a cell surface area similar to the human respiratory tract (RT). However, geometry and air flow rates of an ALI system deviate considerably from the RT. As the tissue-delivered particle dose to the lungs (TD) can hardly be measured, computer models of particle deposition are used here to mimic both the particle deposition at ALI and in the RT. An ALI exposure setup (VitroCell GmbH) for an airflow rate of 100 cm³ min^?1 is selected, where the particle deposition model has been verified experimentally. For the RT we use the hygroscopic lung deposition model of Ferron et al. (2013 Ferron, G. A., S. Upadhyay, R. Zimmermann, and E. Karg. 2013. Model of the deposition of aerosol particles in the respiratory tract of the rat. II. Hygroscopic particle deposition. J. Aerosol Med. Pulm. Drug Deliv. 26 (2):101–19. doi:10.1089/jamp.2011.0965.[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]). Model runs are performed for the particle deposition and for the deposited particles per surface area in both the ALI and the RT. The results show that the ALI-deposited mass is 1-2 orders of magnitude higher than in the alveolar region, because the surface area of the lung region is substantially larger. A particle size range from 40 to 450 nm is identified, where the ratio of both the deposition in a lung region and the deposition at the ALI varies by a factor less than two. Mean values for this ratio are 31 and 101 for the tracheo-bronchial and the alveolar region, respectively. The same size range is found for the ratio of the deposited particles per surface area in a lung region and at the ALI. For this range the mean surface deposition at the ALI is 23- and 1575-times larger than in the tracheo-bronchial and the alveolar lung region, respectively. The effect is partly compensated by different flow rate and cell size.

Copyright © 2020 American Association for Aerosol Research     

The positive effect of hydrogen on the reaction of nitric oxide with carbon monoxide over platinum and rhodium catalysts

The effect of adding 330–4930 ppm hydrogen to a reaction mixture of NO and CO (2000 ppm each) over platinum and rhodium catalysts has been investigated at temperatures around 200–250°C. Hydrogen causes large increases in the conversion of NO and, surprisingly, also of CO. Oxygen atoms from the additional NO converted are eventually combined with CO to give CO₂ rather than react with hydrogen to form water. This reaction is described by CO + NO +3/2H₂ CO₂ + NH₃ and accounts for 50–100% of the CO₂ formed with Pt/Al₂O₃ and 20–50% with Rh/Al₂O₃. With the latter catalyst a substantial amount of NO converted produces nitrous oxide. Comparison with a known study of unsupported noble metals suggests that isocyanic acid (HNCO) might be an important intermediate in a reaction system with NO, CO and H₂ present.     

Herleitung und Validierung eines einfachen Modells zur Beschreibung des Misch- und Entmischungsprozesses beim Feststoffmischen

Discontinuous solids mixing processes are largely carried out over the mixing time. The required mixing time is often determined separately in mixing tests. It remains to be seen whether this corresponds to the optimum. There is a lack of models to describe the mixing quality curve over time. The present article adds a simple, two-parameter model that considers not only the homogenization but also the segregation process. In this way, possible mixing quality optima can be approximated with the help of fewer mixing tests that have been carried out.     

On the complexity of bandwidth allocation in radio networks

We define and study an optimization problem that is motivated by bandwidth allocation in radio networks. Because radio transmissions are subject to interference constraints in radio networks, physical space is a common resource that the nodes have to share in such a way, that concurrent transmissions do not interfere. The bandwidth allocation problem we study under these constraints is the following. Given bandwidth (traffic) demands between the nodes of the network, the objective is to schedule the radio transmissions in such a way that the traffic demands are satisfied. The problem is similar to a multicommodity flow problem, where the capacity constraints are replaced by the more complex notion of non-interfering transmissions. We provide a formal specification of the problem that we call round weighting  . By modeling non-interfering radio transmissions as independent sets, we relate the complexity of round weighting to the complexity of various independent set problems (e.g. maximum weight independent set, vertex coloring, fractional coloring). From this relation, we deduce that in general, round weighting is hard to approximate within n^1−ε$n^{1-\epsilon }$ (n$n$ being the size of the radio network). We also provide polynomial (exact or approximation) algorithms e.g. in the following two cases: (a) when the interference constraints are specific (for instance for a network whose vertices belong to the Euclidean space), or (b) when the traffic demands are directed towards a unique node in the network (also called gathering, analogous to single commodity flow).     

Zeolite based trace humidity sensor for high temperature applications in hydrogen atmosphere

We present a humidity sensor based on H-ZSM-5 type zeolite that is suitable to detect traces of humidity (10–110 ppm_V) under harsh conditions, e.g. reducing atmosphere (H₂) and high temperature (up to 600 °C). By means of complex impedance spectroscopy (IS) we show that the zeolite sensor responds linearly towards minimal changes in humidity. Therefore this result indicates that the zeolite sensor is capable to detect traces of humidity in processes where high temperatures in a hydrogen environment are required.     

Entwicklung Serviceorientierter Architekturen zur Integration von Produktion und Dienstleistung – Eine Konzeptionsmethode und ihre Anwendung am Beispiel des Recyclings elektronischer Geräte

Offering product-service bundles (consisting of products and services) is becoming more important for companies. Modifying the organizational structure of the cooperation as well as adapting to changing customer demands requires versatile information systems. Implementing Service Oriented Architectures (SOA) is one attempt to provide this flexibility. Currently, there is little methodical guidance for the identification, specification and implementation of services as building blocks of Service Oriented Architectures. Accounting for this need, a conceptual approach is designed, which adapts approaches of customer integration, and combines a business and IT analysis. The applicability of the method is demonstrated by designing a Service Oriented Architecture for the recycling of electronic equipment. Implementing services for other product-service bundles will support additional integration scenarios. By standardizing services, a sound integration of products and services can be backed by providing a reference architecture.     

从过程价值的角度出发对集成的客户方案进行定价

Integrating products and services to customized solutions can help firms to differentiate from their competitors. In practice, however, various companies fall short in extracting value from their customers. Therefore this paper focuses on pricing aspects as central means for value appropriation in the context of solutions. Following the resource-based view of the firm, we adopt a process-oriented perspective on pricing practices in order to identify crucial factors and activities. Based on 15 in-depth interviews with practitioners from various industries we derive six steps of a price management process for value appropriation in the context of solution selling and present critical activities and routines within each step.     

BerlinMOD: a benchmark for moving object databases

This document presents a method to design scalable and representative moving object data (MOD) and two sets of queries for benchmarking spatio-temporal DBMS. Instead of programming a dedicated generator software, we use the existing Secondo DBMS to create benchmark data. The benchmark is based on a simulation scenario, where the positions of a sample of vehicles are observed for an arbitrary period of time within the street network of Berlin. We demonstrate the data generator’s extensibility by showing how to achieve more natural movement generation patterns, and how to disturb the vehicles’ positions to create noisy data. As an application and for reference, we also present first benchmarking results for the Secondo DBMS. Whereas the benchmark focuses on range queries, we demonstrate its ability to incorporate new future classes of queries by presenting a preliminary extension handling various nearest neighbour queries. Such a benchmark is useful in several ways: It provides well-defined data sets and queries for experimental evaluations; it simplifies experimental repeatability; it emphasizes the development of complete systems; it points out weaknesses in existing systems motivating further research. Moreover, the BerlinMOD benchmark allows one to compare different representations of the same moving objects.     

Scenario analysis and management options for sustainable river basin management: Application of the Elbe DSS

We developed a decision support system (DSS) for sustainable river basin management in the German Elbe catchment (～100,000 km²), called Elbe-DSS. The system integrates georeferenced simulation models and related data sets with a user friendly interface and includes a library function. Design and content of the DSS have been developed in close cooperation with end users and stakeholders. The user can evaluate effectiveness of management actions like reforestation, improvement of treatment plant technology or the application of buffer strips under the influence of external constraints on climate, demographic and agro-economic changes to meet water management objectives such as water quality standards and discharge control. The paper (i) describes the conceptual design of the Elbe-DSS, (ii) demonstrates the applicability of the integrated catchment model by running three different management options for phosphate discharge reduction (reforestation, erosion control and ecological-farming) under the assumption of regional climate change based on IPCC scenarios, (iii) evaluates the effectiveness of the management options, and (iv) provides some lessons for the DSS-development in similar settings. The georeferenced approach allows the identification of local inputs in sub-catchments and their impact on the overall water quality, which helps the user to prioritize his management actions in terms of spatial distribution and effectiveness.